Publications

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47.- Comaposada-Baró R, Benito-Martínez A, Escribano-Saiz JJ, Franco ML, Ceccarelli L,  Calatayud-Baselga I, Mira H, Vilar M. Cholinergic neurodegeneration and cholesterol metabolism dysregulation by constitutive p75 NTR signaling in the p75 exonIII-KO mice

Frontiers in Molecular Neuroscience. 2023 doi:10.3389/fnmol.2023.1237458

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46.-Del Caño-Ochoa F, Ng BG, Rubio-Del-Campo A, Mahajan S, Wilson MP, Vilar M, Rymen D, Sánchez-Pintos P, Kenny J, Martos ML, Campos T, Wortmann SB, Freeze HH, Ramón-Maiques S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.

J Inherit Metab Dis. 2023 Aug 4. doi: 10.1002/jimd.12667. 

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45.-Brocal-Ruiz R, Esteve-Serrano A, Mora-Martínez C, Franco-Rivadeneira ML, Swoboda P, Tena J, Vilar M, Flames N. Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in C. elegans. eLife. 2023 Jul 14;12:e89702. doi: 10.7554/eLife.89702

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44.-Piccarducci R, Giacomelli C, Bertilacchi MS, Benito-Martinez A, Di Giorgi N, Daniele S, Signore G, Rocchiccioli S, Vilar M, Marchetti L, Martini C.

Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.

Biochim Biophys Acta Mol Basis Dis. 2023 Jun 17;1869(7):166793. doi:10.1016/j.bbadis.2023.166793. Online ahead of print.PMID: 37336366

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43.-Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E.

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.

Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5.PMID: 37280397 

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42.-García-Corzo L, Calatayud-Baselga I, Casares-Crespo L, Mora-Martínez C, Julián Escribano-Saiz J, Hortigüela R, Asenjo-Martínez A, Jordán-Pla A, Ercoli S, Flames N, López-Alonso V, Vilar M , Mira H. The transcription factor LEF1 interacts with NFIX and switches isoforms during adult hippocampal neural stem cell quiescence.

Front Cell Dev Biol. 2022 Jul 22;10:912319. doi: 10.3389/fcell.2022.912319. eCollection 2022.PMID: 35938168 Free PMC article.

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41.- Rafael Ciges-Tomas J, Franco ML, Vilar M.Identification of a guanine-specific pocket in the protein N of SARS-CoV-2. Commun Biol. 2022 Jul 16;5(1):711. doi: 10.1038/s42003-022-03647-8.PMID: 35842466 

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40.- EF Kot, ML Franco, EV Vasilieva, AV Shabalkina, AS Arseniev, S Goncharuk, K Mineev, M Vilar. Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors. iScience, 2022 104348

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39.- Francisco-Velilla R, Embarc-Buh A, Del Caño-Ochoa F, Abellan S, Vilar M, Alvarez S, Fernandez-Jaen A, Kour S, Rajan DS, Pandey UB, Ramón-Maiques S, Martinez-Salas E.

Functional and structural deficiencies of Gemin5 variants associated with neurological disorders.

Life Sci Alliance. 2022 Apr 7;5(7):e202201403. doi: 10.26508/lsa.202201403. Print 2022 Jul.

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38.-Vilar M.

Neurotrophin receptors, gamma-secretase inhibitors, and neurodegeneration of basal forebrain cholinergic neurons

Neural Regeneration Research 2022, 17 (7), 1493  

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37.- Franco ML, Nadezhdin KD, Light TP, Goncharuk SA, Soler-Lopez A, Ahmed F, Mineev KS, Hristova K, Arseniev AS, Vilar M.

Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation.

J. Biol. Chem. 2021 Aug;297(2):100926

doi:   10.1016/j.jbc.2021.100926

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36.- Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard, et al.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

Autophagy 2021Feb 3;4(4):e202000844.

doi: 10.1080/15548627.2020.1797280

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35.-Franco ML, García-Carpio I, Comaposada-Baró R, Escribano-Saiz JJ, Chávez-Gutiérrez L,Vilar M, 

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition 

Life Science Alliance 2021 Feb 3;4(4):e202000844. doi: 10.26508/lsa.202000844

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34.- Fernández A, Quintana E, Velasco P, Moreno-Jimenez B, de Andrés B, Gaspar ML, Liste I, Vilar M, Mira H, Cano E. 

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation.

J Neuroinflammation. 2021 Mar 18;18(1):75. doi: 10.1186/s12974-021-02104-3.PMID: 33736657 

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33.-Franco ML, Nadezhdin KD, Goncharuk SA, Mineev KS, Arseniev AS, Vilar M.

Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor.

J Biol Chem. 2020 Jan 3;295(1):275-286. doi: 10.1074/jbc.RA119.011312. PMID: 31801826

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32.-Matamala N, Lara B, Gomez-Mariano G, Martínez S, Retana D, Fernandez T, Silvestre RA, Belmonte I, Rodriguez-Frias F, Vilar M, Sáez R, Iturbe I, Castillo S, Molina-Molina M, Texido A, Tirado-Conde G, Lopez-Campos JL, Posada M, Blanco I, Janciauskiene S, Martinez-Delgado B 

Characterization of Novel Missense Variants of SERPINA1 Gene Causing Alpha-1 Antitrypsin Deficiency.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):706-716. doi: 10.1165/rcmb.2017-0179OC.PMID: 29232161 

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31.- Cortegano I, Rodríguez M, Martín I, Prado MC, Ruíz C, Hortigüela R, Alía M, Vilar M, Mira H, Cano E, Domínguez M, de Andrés B, Gaspar ML 

Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses.

Cell Death Dis. 2017 Aug 17;8(8):e3000. doi: 10.1038/cddis.2017.351.PMID: 28817118 

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30.-Vilar M.

Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily.

Vitam Horm. 2017;104:57-87. doi: 10.1016/bs.vh.2016.10.007. Epub 2016 Nov 29. PMID: 28215307 Review.

 

29.- Franco ML, Melero C, Sarasola E, Acebo P, Luque A, Calatayud-Baselga I, García-Barcina M, Vilar M. 

Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Misfolding, Aggregation, and Mutation-dependent Neurodegeneration by Dysfunction of the Autophagic Flux.

J Biol Chem. 2016 Oct 7;291(41):21363-21374. doi: 10.1074/jbc.M116.722587. Epub 2016 Aug 22.PMID: 27551041 

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28.- Nadezhdin KD, García-Carpio I, Goncharuk SA, Mineev KS, Arseniev AS, Vilar M.

Structural Basis of p75 Transmembrane Domain Dimerization.

J Biol Chem. 2016 Jun 3;291(23):12346-57. doi: 10.1074/jbc.M116.723585. Epub 2016 Apr 7.PMID: 27056327 

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27.- Vilar M, Mira H.

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.

Front Neurosci. 2016 Feb 9;10:26. doi: 10.3389/fnins.2016.00026. eCollection 2016.PMID: 26903794 Review.

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26.- Mineev KS, Goncharuk SA, Kuzmichev PK, Vilar M, Arseniev AS.

NMR Dynamics of Transmembrane and Intracellular Domains of p75NTR in Lipid-Protein Nanodiscs.

Biophys J. 2015 Aug 18;109(4):772-82. doi: 10.1016/j.bpj.2015.07.009.PMID: 26287629 

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25.- Fernandez EM, Díaz-Ceso MD, Vilar M.

Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs.

PLoS One. 2015 Jan 22;10(1):e0117206. doi: 10.1371/journal.pone.0117206. eCollection 2015.PMID: 25612294 

 

24.- Vilar M, Sung TC, Chen Z, García-Carpio I, Fernandez EM, Xu J, Riek R, Lee KF.

Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.

PLoS Biol. 2014 Aug 5;12(8):e1001918. doi: 10.1371/journal.pbio.1001918. eCollection 2014 Aug.PMID: 25093680 

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23.- Díaz-Moreno M, Hortigüela R, Gonçalves A, García-Carpio I, Manich G, García-Bermúdez E, Moreno-Estellés M, Eguiluz C, Vilaplana J, Pelegrí C, Vilar M, Mira H.

Aβ increases neural stem cell activity in senescence-accelerated SAMP8 mice.

Neurobiol Aging. 2013 Nov;34(11):2623-38. doi: 10.1016/j.neurobiolaging.2013.05.011. Epub 2013 Jun 22.PMID: 23796660

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22.- Sung TC, Chen Z, Thuret S, Vilar M, Gage FH, Riek R, Lee KF.

P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.

PLoS One. 2013 Jul 23;8(7):e69286. doi: 10.1371/journal.pone.0069286. Print 2013.PMID: 23935974 

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21.-Vilar M, Wang L, Riek R.

Structural studies of amyloids by quenched hydrogen-deuterium exchange by NMR.

Methods Mol Biol. 2012;849:185-98. doi: 10.1007/978-1-61779-551-0_13.PMID: 22528091

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20.- Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R.

In vivo demonstration that alpha-synuclein oligomers are toxic.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. doi: 10.1073/pnas.1100976108. Epub 2011 Feb 15.PMID: 21325059 

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19.-Tamborero S, Vilar M, Martínez-Gil L, Johnson AE, Mingarro I.

Membrane insertion and topology of the translocating chain-associating membrane protein (TRAM).

J Mol Biol. 2011 Mar 4;406(4):571-82. doi: 10.1016/j.jmb.2011.01.009. Epub 2011 Jan 13.PMID: 21237175 

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18.- Perrinjaquet M, Vilar M, Ibáñez CF.

Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.

J Biol Chem. 2010 Oct 8;285(41):31867-75. doi: 10.1074/jbc.M110.144923. Epub 2010 Aug 3.PMID: 20682772 

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17.- Ruiz EJ, Vilar M, Nebreda AR.

A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry.

Curr Biol. 2010 Apr 27;20(8):717-23. doi: 10.1016/j.cub.2010.02.050. Epub 2010 Apr 1.PMID: 20362450 

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16.- Shirazi Fard S, Kele J, Vilar M, Paratcha G, Ledda F.

Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth.

PLoS One. 2010 Mar 19;5(3):e9647. doi: 10.1371/journal.pone.0009647.PMID: 20333299 

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15.-Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF.

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor.

J Cell Sci. 2009 Sep 15;122(Pt 18):3351-7. doi: 10.1242/jcs.055061. Epub 2009 Aug 25.PMID: 19706676 

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14.- Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ibáñez CF.

Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.

Neuron. 2009 Apr 16;62(1):72-83. doi: 10.1016/j.neuron.2009.02.020.PMID: 19376068 

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13.-Vilar M, Chou HT, Lührs T, Maji SK, Riek-Loher D, Verel R, Manning G, Stahlberg H, Riek R.

The fold of alpha-synuclein fibrils.

Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8637-42. doi: 10.1073/pnas.0712179105. Epub 2008 Jun 12.PMID: 18550842 

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12.-Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G.

Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF.

J Neurosci. 2008 Jan 2;28(1):39-49. doi: 10.1523/JNEUROSCI.2196-07.2008.PMID: 18171921 

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11.- Mingarro I, Lukovic D, Vilar M, Pérez-Gil J.

Synthetic pulmonary surfactant preparations: new developments and future trends.

Curr Med Chem. 2008;15(4):393-403. doi: 10.2174/092986708783497364.PMID: 18288994  Review.

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10.- Martínez-Gil L, Saurí A, Vilar M, Pallás V, Mingarro I.

Membrane insertion and topology of the p7B movement protein of Melon Necrotic Spot Virus (MNSV).

Virology. 2007 Oct 25;367(2):348-57. doi: 10.1016/j.virol.2007.06.006. Epub 2007 Jul 3.PMID: 17610929 

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9.- Vilar M, Murillo-Carretero M, Mira H, Magnusson K, Besset V, Ibáñez CF.

Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle.

EMBO J. 2006 Mar 22;25(6):1219-30. doi: 10.1038/sj.emboj.7601017. Epub 2006 Feb 23.PMID: 16498402 

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 8.- Vilar M, Saurí A, Marcos JF, Mingarro I, Pérez-Payá E.

Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding.

Chembiochem. 2005 Aug;6(8):1391-6. doi: 10.1002/cbic.200400451.PMID: 16003802

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7.- Mira H, Vilar M, Esteve V, Martinell M, Kogan MJ, Giralt E, Salom D, Mingarro I, Peñarrubia L, Pérez-Payá E.

Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein.

BMC Struct Biol. 2004 Jun 4;4:7. doi: 10.1186/1472-6807-4-7.PMID: 15180901 Free PMC article.

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6.- Aparicio F, Vilar M, Perez-Payá E, Pallás V.

The coat protein of prunus necrotic ringspot virus specifically binds to and regulates the conformation of its genomic RNA.

Virology. 2003 Aug 15;313(1):213-23. doi: 10.1016/s0042-6822(03)00284-8.PMID: 12951034 Free article.

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5.- Vilar M, Saurí A, Monné M, Marcos JF, von Heijne G, Pérez-Payá E, Mingarro I.

Insertion and topology of a plant viral movement protein in the endoplasmic reticulum membrane.

J. Biol Chem. 2002 Jun 28;277(26):23447-52. doi: 10.1074/jbc.M202935200. Epub 2002 Apr 25.PMID: 11976343 

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4.- Mira H, Vilar M, Peñarrubia MD and Perez-payá E.

Functional and conformational properties of the exclusive C-domain from the Arabidopsis copper chaperone (CCH)

Biochemical Journal 2001 357 (2), 545-549

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3.- M Vilar, V Esteve, V Pallás, JF Marcos, E Pérez-Payá

Structural properties of carnation mottle virus p7 movement protein and its RNA-binding domain

Journal of Biological Chemistry 276 (21), 18122-18129

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2.- Marcos JF, Vilar M, Pérez-Payá E, Pallás V.

In vivo detection, RNA-binding properties and characterization of the RNA-binding domain of the p7 putative movement protein from carnation mottle carmovirus (CarMV).

Virology. 1999 Mar 15;255(2):354-65.

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1.- Vilar M, Carbonell T, Pérez-Payá E.

[Combinatorial chemistry and biomedicine: a new strategy in the development of antibiotics]. Rev Esp Quimioter. 1998 Dec;11(4):287-94. Review. Spanish.

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